While Norman blames Iron Man for the attack and threatens legal action, Spider-Man recovers a tentacle from an Octo-Bot and learns more about Doctor Octopus' history with both Oscorp, Doctor Connors and Norman himself. Academy students, Spider-Man is caught off guard when it turns out Rhino was not the mole Doc Ock just used him to break free and that there is a seventh member of Doctor Octopus' group that Spider-Man least suspects: Scarlet Spider. Part 2: Now that Doctor Octopus knows that Spider-Man is Peter Parker, he sends Scarlet Spider to claim a key that Spider-Man hid at Aunt May's house. While the others face off against Doctor Octopus, Spider-Man and Power Man work with to enter Nick Fury's body and get the Octo-Bots out of him, with help to Iron Spider create a special submarine. Once the Ankh is safe, Fury sends the team and Blade to retrieve the second half from storage in a museum before Dracula can get to it. Impressed by Spider-Man's scientific knowledge, Iron Man builds him a high-tech armor suit called the , which is equipped with an array of powerful weaponry. At the end, finds a sample of the venom and trains it.
Upon encountering the precognitive , Spider-Man and Triton discover that Nick Fury is the prisoner of and the Hydra Agents with him. For her safety, Spider-Man allows her to enter the Sanctorum only to discover that she is Francis Beck, the daughter of his presumed deceased enemy. After exploding, Carnage starts to infect all of Manhattan. The Norse thunder god arrives to aid Spider-Man's team, but magic from a medallion around the Giant's neck turns Thor into a talking frog. The series premiered on on April 1, 2012, airing alongside , as part of the Marvel Universe block. Ock also receives an upgrade to his armor, gaining a much more sinister appearance. As he ends up breaking out while Spider-Man brings Aunt May to the graduation, Doctor Octopus and his new Sinister Six break free as he ensnares Aunt May.
When the choices , , , , , and prove unpopular, Spider-Man and his team go to to track down. As Doctor Octopus terrorizes the city, Spider-Man uses the same serum on Vulture, Crossbones, and Rhino to depower them while also defeating Kraven the Hunter and Scorpion. The team follow Thor to , where the power-hungry is working with the Frost Giants to seize the Asgardian throne at the time when is in his Odinsleep. They instead go against their orders and sneak off to a deserted tropical island which Nova finds on the S. Spider-Man and Captain America try to sneak into the Latverian embassy and retrieve the shield before Doctor Doom has a chance to exploit it for his own nefarious purposes. Without the support of S.
Jessie finds a medieval sword coveted by while unknowingly freeing her from her imprisonment. Peter then discovers the hero's true identity, his friend Harry Osborn, bonded with the Venom symbiote, and he tries to persuade Harry to get rid of it before it corrupts his mind and turns him evil. Even when most of the Sinister Six is defeated by the S. While Spider-Man, Iron Spider, and Kid Arachnid fight Hydro-Man, Scarlet Spider works to protect Aunt May who ends up naming him. Academy, he is visited by Doctor Octopus who threatens to harm Aunt May if he puts on the Spider-Man costume again. Jessie and Spider-Man work to save Halloween and the world from the evil plans of le Fay's and henchman which she created from a security guard.
Then Spider-Man and Kid Arachnid arrive in a dimension where they meet the spider-themed cowboy Webslinger who lost his Uncle Ben who was a sheriff when Doc Ock Holliday took over the town. But Doctor Octopus turns on them when they get to his former hideout for the truth about Vulture's past though eventually both Spider-Man and Vulture eventually take him down. After rounding up Kraven the Hunter, the Rhino, the Scorpion and the Vulture as well as turning Crossbones into a Lizard, Doctor Octopus allows himself to be incarcerated in the Triskelion's security brig by Spider-Man´s team. Spider-Man and Agent Venom are the last line of defense with help from Hulk. Disgruntled Stark Industries scientist Michael Tan uses a machine of his invention to separate his own atoms and his consciousness takes control of the Spider-Tracers, creating a driven by hatred towards Tony Stark. Part 2: While chasing Green Goblin across the Multiverse, Spider-Man arrives in the universe where he helps renew his friendship with Marry Jane.
Spider-Man doesn't know it yet, but Hulk is actually fighting. Part 4: Grandmaster has won the Contest of Champions and claims Manhattan for the bad guys. Once Hydro-Man is defeated where the resulting battle watered Aunt May's lawn, Spider-Man gets word that the Quinjet carrying Hydro-Man back to his cell was intercepted causing Spider-Man to speculate that Doctor Octopus has gotten Hydro-Man on his side. At school, Peter and Luke notice Flash Thompson is bullying a shy, nerdy classmate named Alex O'Hirn. With Thor also having been shrunk, Spider-Man's team must find a way to help Thor fight Loki and the and return to normal size. Spider-Man discovers that he has been chosen to be the chief game piece of the against who seeks to submit the Earth and once again humiliate his brother. When Scarlet Spider is persuaded by Aunt May to help Spider-Man, he seemingly sacrifices his life in order to crash Octopus Island into the ocean as Sandman defeats Hydro-Man.
Nick Fury has Spider-Man's team placed in the Helicarrier's D. Spider-Man, Iron Spider, and Kid Arachnid were unable to find Scarlet Spider's body. Note: Norman Osborn is revealed to be aware of Spider-Man's identity as Peter Parker for some time after recovering the memories of his time as the Green Goblin. After experiencing each one, Spider-Man must fight Nightmare to get out of this nightmare and learn the meaning of being a hero who needs it most. However, Hulk and Rhino face in battle and only Spider-Man and Agent Venom should stop now so to not cause destruction. Driven by its desire to bond with Peter, the creature escapes from the laboratory, tracks him down to a house party and wreaks havoc, jumping from host to host and possessing each of Peter's teammates.
For the third game, Spider-Man is partnered with Power Man, Black Widow, and against Doctor Octopus, , and Zzzax in a game of last team standing. With the help of Norman Osborn, Spider-Man is able to regain his powers with the radioactive spider in Doctor Octopus' hidden lab and confront the Superior Sinister Six when they arrive at Oscorp upon noticing that Norman Osborn wasn't there. Note: Mary Jane Watson becomes aware of Spider-Man, Agent Venom and Patrioteer's identities as Peter Parker, Flash Thompson and Harry Osborn, respectively. With the help of Thor and the entire S. Both heroes must adjust to their different powers and mindsets to defeat and to get Mesmero to switch their minds back. Meanwhile, Mary Jane rounds up Agent Venom, Iron Spider and Kid Arachnid to meet up with Spider-Man to show her transformation as Spider-Woman.
Spider-Man finds the Siege Perilous fragment in the new machine gun that was provided by Hammerhead's minion Martin Li. In order to deal with Hydro-Man, Spider-Man has awaken Sandman to fight him. Using the shard of the Siege Perilous, Spider-Man and Kid Arachnid are sent on a trip to the different dimensions to collect the shards. Spider-Man is frustrated by this seemingly boring assignment, but he begins to suspect criminal activity within Damage Control when he notices their Mac Porter acting suspiciously. Their next stop is a cartoon-like pirate dimension where the spider-themed pirate Web Beard is persuaded by Spider-Man and Kid Arachnid into reuniting his animal crew consisting of pirate versions of , Rocket Raccoon, and so that they can face the on a pirate ship version of Groot. Jameson begrudgingly asks for Spider-Man's help to hunt down his missing son, on the moon.
Now they help Webslinger build up the courage to fight corrupt sheriff Doc Ock Holliday and his deputy who previously repelled Wolf Spider. Note: Harry Osborn becomes aware of Spider-Man, Agent Venom and all their teammates identities respectively. When Kaine gets control of the Delta-Nine Synthezoids, Spider-Man and the other spider-based heroes defeat Kaine after he combines with the Delta-Nine Synthezoids to form a hybrid form. Spider-Man visits Doctor Strange, who claims that the responsible spell is on a quantum level. When Wolf Spider gets involved by holding Rio Morales hostage, Spider-Man, Kid Arachnid, and Spider-Woman work to stop Wolf Spider.